Kinetic study on the inhibition of xanthine oxidase by acylated derivatives of flavonoids synthesised enzymatically
نویسندگان
چکیده
منابع مشابه
Inhibition of xanthine oxidase by flavonoids.
Various dietary flavonoids were evaluated in vitro for their inhibitory effect on xanthine oxidase, which has been implicated in oxidative injury to tissue by ischemia-reperfusion. Xanthine oxidase activity was determined by directly measuring uric acid formation by HPLC. The structure-activity relationship revealed that the planar flavones and flavonols with a 7-hydroxyl group such as chrysin,...
متن کاملThe inhibition of xanthine oxidase by flavonoids and related compounds.
Investigations of the inhibition of the activity of xanthine oxidase in vitro have yielded a number of substances which have been reported to exert marked inhibitory actions at low concentrations. Among these are p-aminophenol in its oxidized form (l), pyrogallol (a), bromoacetophenone (3)) 6-pteridylaldehyde (4)) and 6-hydroxymethylpterin (5). An examination of the structures of these compound...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2017
ISSN: 1475-6366,1475-6374
DOI: 10.1080/14756366.2017.1347165